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My parent's dog recently became seriously ill. Pepper lost the majority of her hair, had oozing sores and was completely miserable. After finally taking her to a pet dermatologist they found the cause of her problems. They tried this new flea and tick medicine called Promaris (also spelled Premeris) and she now has pemphigus foliaceus, a condition where the immune system attacks the skin causing blisters, pustules and crusting erosions. It can be deadly if left untreated. Thankfully they figured out what was wrong before it was too late, but Pepper will have to be on medicine for the rest of her life.